Objective To observe the symptoms of juvenile Rhesus monkey taking orally melamine and melamine analog. Symptoms including:kidney damage, kidney stone, process of kidney damage reversibility. Methods6month old rhesus monkeys were chosen, half male and half female, randomly divided into 3 groups, each group has 2 monkeys. group T1(melamine,140 mg/kg; cyanuric acid,14 mg/kg), group T2 (melamine, 140 mg/kg; adenine, 50 mg/kg), and group T3(melamine,140 mg/kg). Each group was given its own dose for 10 weeks. Then the animal’s daily condition was observed, and their CBC, blood chemistry, urine routine and B scan were tested at different time point. The animals were kept for 18 months; their growth and development condition were observed. Results 1.At each group, lots of stones was found on the kidney after administering drug for 8 weeks. After stopping administration, all stones became smaller and less, and no stone could be tested till stopping test articles for 16 months. 2. At each group, β2-MG and UA in blood serum was increased after administration, but all of them fluctuated in normal limit; and in reversibility, β2-MG and UA were lower than before. Conclusions1. melamine (48mg/kg.w.d as in human body ) could not cause Rhesus monkey kidney damage ,but can cause kidney stone. 2. When cyanuric acid and adenine existed, melamine could increased β2-MG and UA in normal range and also could cause kidney stone. 3. The stone of all animals couldn’t be detected for 16 months, the animals of oral melamine recovered faster. 