Objective To make a reproducible diabetes mellitus model in macaques intravenous injection with low dose streptozotocin(STZ). Methodswe used STZ (30 mg/kg of body weight, intravenously, 3 days) to five macaques. The dynamic changes of the kidney related biochemistry index and routine urinalysis were measured for 13 months after the glucose is stable. ResultsAnimal’s average glucose is table at 10 week(8.31±2.31 mmol/L). Compared with the contents before injection, TP, GLOB, TG increased significantly at 10 and 9 months (P < 0.05)while A/G reduced in plasma in macaques 11 months after streptozotocin injection(P < 0.01). GSP have significant difference at 6 months (P < 0.05) and great significant difference at 9 months (P < 0.01). Significantly positive correlations were observed between Glu and TP, GLOB, UREA, CR, Mg²⁺, GSP. Significantly negative correlations were observed between Glu and A/G. ConcusionThe present Diabetes Mellitus model in nonhuman primate mimics human early stage of DN and may be useful in assessing safety and efficacy of protective agents.