The Role of Farnesoid X Receptor in Diabetic Nephropathy
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    Abstract:

    Diabetic Nephropathy is well known as complication of microvessel disease caused by diabetes. High glucose leads to compensable high filtration rate of kidney,and then contribute to kidney cell groth, inflammation and fibrosis. Farnesoid X Receptor has been proved to ameliorate diabetic nephropathy. FXR can improve diabetic nephropathy through different aspects such as glucose, lipid, inflammation and fibrosis. How FXR improve diabetic nephropathy will be discussed in this review.

    Reference
    [1] 《中国糖尿病防治指南》编写组.中国糖尿病防治指南[M].北京:北京大学医学出版社,2004.6.
    [2] 张浩军,李平,赵静波等.糖肾方对糖尿病肾病大鼠肾组织TGF-l31及MMP-9表达的影响[J].中国中西医结合肾病杂志 9,0(4):290-294.
    [3] Ronald Pyram,Abhishek Kansara,Mary Ann Banerji.Chronic kidney disease and diabetes[J].Maturitas ,2,1:94-103.
    [4] Devasmita Choudhury,Moshe Levi.Kidney aging-inevitable or preventable? [J]Nephrol,1,7:706-717.
    [5] Chawla A.Repa JJ,Evans RM,M angelsdorf DJ.Nuclear receptors and lipid physiology:opening the X—files[J].Science, 1,4:1866-l870.
    [6] Makishima M,Okamoto A Y,Repa J J,et al.Identification of a nuclear receptor for bile acids[J].Science ,9,4:1362-1365.
    [7] Parks D J,Blanchard S G,Bledsoe R K,et al.Bile acids:natural ligands for an orphan nuclear receptor[J].Science,9,4:1365-1368.
    [8] Wang H,Chen J,Hollister K,et al.Endogenous bile acids are ligands for the nuclear receptor FXR/BAR[J].Mol.Cell, 9,3:543-553.
    [9] Forman B M,Goode E,Chen J,et al.Identification of a nuclear receptor that is activated by farnesol metabolites[J].Cell, 5,1:687-693.
    [10] Seol W,Choi H S,Moore D D.Isolation of proteins that interact specifically with the retinoid X receptor:two novel orphan receptors[J].Mol.Endocrinol, 5,9:72-85.
    [11] Claudel T,Staels B,Kuipers F.The farnesoid X receptor-A molecular link between bile acid and lipid and glucose metabolism[J].Arterioscler.Thromb.Vasc.Biol, 5,5:2020-2031.
    [12] Duran-Sandoval D,Cariou B,Fruchart JC,et al.Potential regulatory role of the farnesoid X receptor in the metabolic syndrome[J].Biochimie,5,7:93-98.
    [13] Schnaper HW, Hayashida T, Poncelet AC.It''s a Smad world:regulation of TGF-beta signaling in the kidney[J].J Am Soc Nephrol,2,3:1126-8.
    [14] Gwon-Soo Jung, Mi-Kyung Kim, Mi Sun Choe.The Orphan Nuclear Receptor SHP Attenuates Renal Fibrosis[J].J Am Soc Nephrol,9,0:2162-2170.
    [15] Wang YD, Chen W-D,Wang M,et al.Farnesoid X receptor antagonizes NF-κB in hepatic inflammatory response[J].Hepatology,8,8(5):1632-1643.
    [16] Gadaleta Raffaella M,Oldenburg Bas,Willemsen Ellen C.L.,et al.Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine[J].Biochimicaet Biophysica Acta, 1,2:851-858.
    [17] Shen Hong,Zhang Yu,Ding Hong,et al.Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter[J].Cell.Physiol.Biochem,8,2:1-14.
    [18] Popescu Iuliana Ristea,Helleboid-Chapman Audrey,Lucas Anthony,et al.The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity[J].FEBS Lett,0,4:2845-2851.
    [19] Zhang YQ,Lee FY,Barrera G,et al.Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice[J].Proc.Natl.Acad.Sci.U.S.A,6,3:1006-1011.
    [20] Cariou B,van Harmelen K,Duran-Sandoval D,et al.The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice[J].J.Biol.Chem,6,1:11039-11049.
    [21] Leiss O,von Bergmann K.Different effects of chenodeoxycholic acid and ursodeoxycholic acid on serum lipoprotein concentrations in patients with radiolucent gallstones[J].Scand.J.Gastroenterol,2,7:587-592.
    [22] Lambert G,Amar MJA,Guo G,et al.The farnesoid X-receptor is an essential regulator of cholesterol homeostasis[J].J.Biol.Chem,3,8:2563-2570.
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