Study on dynamic changes and gender difference of heart rate variability and blood pressure variability via implantable telemetry technology in spontaneously hypertensive rats
Author:
  • Article
  • | |
  • Metrics
  • |
  • Reference [14]
  • | | | |
  • Comments
    Abstract:

    Objective To observation dynamic changes and gender difference of heart rate variability and blood pressure variability in unbonded spontaneously hypertensive rats using Telemetry technology. Method Taking sixteen spontaneously hypertensive rats of 3-month-old in SPF grade, there were implanted TL11M2-C50-PXT device intraperitoneally. Seven days later, respectively monitoring chainless blood pressure and electrocardiogram for 24 h continuously time using telemetry system when 3, 5, 7 months of age in spontaneously hypertensive rats. Analysing 24 h systolic pressure, mean blood pressure, diastolic blood pressure, heart rate variability and blood pressure variability. Result Systolic pressure, diastolic pressure and mean pressure, blood pressure variability increased with age of the moon increased in spontaneously hypertensive rats, moreover female SHR rats of blood pressure variability was significantly lower than that of the male rats. Correlated indexes of heart rate variability had no obvious change Between three to seven month-old in male spontaneously hypertensive rats. But RR interval, SDNN, TP, VLF and HF increased significantly with age of the moon increased in female spontaneously hypertensive rats, moreover the female SHR rats of TP, VLF and HF index of heart rate variability were lower than the male rats. Conclusion With the SHR rats age and blood pressure, blood pressure variability increased, and the female SHR rat variability in blood pressure and heart rate was significantly lower than that of the male.

    Reference
    [1] Kienzle MG, Fergnsom DM, Birrett CL, et al. Clinical, hemodynamic and sympathetic neural correlates of heart rate variability in congestive heart failure[J]. Am J Cardial, 1992, 69 (8):761-767.
    [2] Parati G, Faini A, Valentini M. Blood pressure variability: its measurement and significance in hypertension.Curr Hypertens Rep,2006,8(3):199-204.
    [3] 戴生明,苏定冯. 自发性高血压大鼠压力反射敏感性与血压变异性的关系[J]. 中国心血管病杂志.1998,26(5):346-349.
    [4] Kurtz TW, Griffin KA, Bidani AK, et al. Recommendations for blood pressure measurement in human and experimental animals Part 2: blood pressure measurement in experimental animals [J]. Hypertension, 2005, 45(2): 299- 310.
    [5] 袁海涛,汪滢,夏静,等. 应用清醒大鼠遥测模型评价 AF114 注射液的心血管系统的安全性[J]. 中国新药杂志. 2011,20(22):2188-2189.
    [6] 梁月琴,王蕾,张明升,等.清醒大鼠血压不同测量方法的结果比较[J]. 山西医科大学学报. 2005,36(3):282-283.
    [7] 葛蓓蕾,金树兴,邢金山. 影响实验动物福利的因素及改善措施[J].实验动物科学,2008, 25(4):73-75.
    [8] 寿旗扬,潘永明,陆晔枫,等. 应用植入式遥测技术观察自发性高血压大鼠血压的昼夜波动[J]. 中国实验动物学报.2013,21(4): 52-56.
    [9] Maarten van, Nico Wegener. Involvement of serotonin1A receptors in cardiovascular responses to stress: a radio-telemetry study in four rat strains[J]. European Journal of Pharmacology,2005, 507(1-3) :187-198.
    [10] 杨建泉. 维持性血液透析患者的心率变异性分析[J]. 中国血液净化,2005,4(10):561- 562.
    [11] 杨玉伟,陈民利,潘永明,等. 长途运输应激对两种品系五指山小型猪自主神经功能的影响[J]. 实验动物与比较医学,2010,30(5) : 359-364.
    [12] Van Ravenswaaij-Arts CMA, Kollee LAA, Hopman JCW, et al. Heart rate variability[J].Ann Internal Med,1993,118(6) :436-447.
    [13] Yamasaki F, Seo H, Furuno T, Hamashige N, et al. Effect of age on chronological variation of acute myocardial infarction onset: study in Japan[J]. Clin Exp Hypertens. 2002,24(1-2):1-9.
    [14] Duncan MJ, Grear KE, Hoskins MA. Aging and SB-269970-A, a selective 5-HT7 receptor antagonist, attenuate circadian phase advances induced by microinjections of serotonergic drugs in the hamster dorsal raphe nucleus[J]. Brain Res. 2004,15 (1):40-48.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation
Share
Article Metrics
  • Abstract:2090
  • PDF: 1716
  • HTML: 0
  • Cited by: 0
History
  • Revised:November 24,2014
  • Online: January 29,2015
Article QR Code