Objective To evaluate the efficacy, safety and compatibility of a new type of atrial septal defect (ASD) occluder in atrial spetal defect mini-pigs model. Methods Five Tibet mini-pigs were selected as the ASD models which were established by the combination of atrial septal puncture and balloon dilation. Then the new type occluder was implanted for the therapy of ASD. Transthoracic echocardiography with color Doppler was used in all animals during closure and in follow up examinations. The animals were killed at 3 months after occlusion for electron microscopical observation and microscopic examination. Result The ASD models had been created in five piglets successfully without complication, all of whom were implanted successfully with the new device without shunts. Postmortem and microscopic examination of the 5 specimens 3 months after placement showed complete. Conclusion Transcatheter ASD occlusion with new type ASD occluder is safe,feasible and effective. This occlusion can repair the atrial septal defect successfully.