Objective To optimize the background of the congenital cataract in rats, the blood pressure, body temperature and weight of rats were measured and correlation analysis. Methods We took three kinds of rats(cataracts rat,microphthalmos cataracts rat and normal rat)as subjects, each kind with half males and females was divided into three groups by weight, each of which contains 30 rats. We used the Multi-channel physiological signal acquisition system for test. Results Blood pressure has no significant difference among the three segments of male and female rats(P > 0.05). With the increase of body weight,blood pressure and body weight formed a relevant relationship gradually.In the same male strain,there was significant difference between the standard weight(207 g) and the aging weight(494 g)(P < 0.01). In the same body weight range, the temperature difference between male and female rats was significant(P < 0.01),and the male's temperature was lower than the female. Conclusions The changes in blood pressure,body weight and temperature of cataract rats conformed to the physiological characteristics of rats,which provide a theoretical basis for the use of catatacts rats in the future