Objective To explore the application of a quality control circle (QCC) for reducing the rate of non?standardized behaviors in animal experiments. Methods A QCC team named “Love and Welfare” was set up. According to the steps of QCC activity, the causes of non?standardized behaviors during animal experiments of the researchers in our hospital were analyzed, and the related countermeasures were formulated and implemented. Results Through this QCC activity, the rate of non?standardized behaviors occurred during animal experiments in our hospital was reduced from 82. 5 times to 22. 33 times per week. Conclusions QCC activity has significant effects on reducing the rate of non?standardized behaviors and can be used for enhancing the quality of animal experiment management.