The protein tyrosine phosphorylation signal pathways are important signal transduction pathways, which are widely present in cells. Their function is closely related to cell proliferation, differentiation, transformation and apoptosis. Alzheimer’s disease (AD) is a degenerative disease of the nervous system. Age is the greatest risk factor for AD, and the likelihood of suffering from AD is age dependent. The main pathological features are the aggregation of β- amyloid protein and abnormal phosphorylation of Tau protein. The treatment of AD with tyrosine kinase inhibitors has become a greatly discussed topic in modern medical research. Therefore, the basic research progress of the relationship between the protein tyrosine phosphorylation signaling pathways and AD is briefly reviewed in this paper.