With the deepening of research on the modernization of Chinese medicine, disease animal model are widely used to study the basic theories of traditional Chinese medicine, treatment evaluation and mechanism of traditional Chinese medicine efficacy. This article comprehensive review the research and development status of disease animal models of traditional Chinese medicine, concluded the research ideas and method for the establishment and evaluation of disease animal models of traditional Chinese medicine and discusses the existing problems. The future development directions in this field are pointed out and may provide reference for further research.