The nuclear factor erythroid-2-related factor2 (Nrf2) / antioxidant response element (ARE) signaling pathway is an essential antioxidant pathway regulated by redox. Activation of this pathway plays an important role in regulating oxidative stress, maintaining mitochondrial function, inhibiting ferroptosis in dopaminergic neurons and ptotecting them against oxidative damage. Targeting this pathway for the treatment of Parkinson’ s disease ( PD) has become a research focus. In this review, we summarize and analyze the current research on the Nrf2-ARE pathway, including the mechanisms, function and relation with PD. These insights may help further clarify the relationship between Nrf2-ARE pathway and PD and aid in developing new ideas for new PD drugs targeting the Nrf2-ARE pathway.