Objective To observe the dynamic change of pathological indexes in MRL/lpr mice and explore the relationship between expression of SIGIRR in kidney tissue and the pathological grade of lupus nephritis, which suggested whether TLR4/NF-κB signal pathway was involved in the development of LN. Methods There were 12 control mice C57BL/6 and 12 model mice MRL/lpr and then their thymus and spleen index 、proteinuria 、BUN、ANA were detected at 12week、15week、18week and 21week respectively. And kidney frozen sections were stained with HE and Masson to study the pathological grade of LN. At last, IHC and western blot was used to analyze the expression of SIGIRR in kidneys of mice at different ages. Results Proteinuria of MRL/lpr mice increased from 12week to 21week when compared with control mice at the same age, while BUN and ANA had no significant increase as time went by. HE and Masson staining showed that model mice began to develop glomerulonephritis, diffuse infiltration of inflammatory cells surrounding vessels at 12 week, and then kidney interstitial fibrosis, Glomerular mesangial and basement membrane thickening, and even the glomerular fibrosis and sclerosis. However expression of SIGIRR in kidney of MRL/lpr mice at 21 week had significant increase when compared with that of C57BL/6 mice by western blot and IHC. Conclusion Expression of SIGIRR increased following the LN development, and it may be involved in the TLR4/NF-κB signal pathway.