Objective To analyze the difference of growth and organ coefficient between mutant mice and normal mice using inbred BALB/c curly mutant mouse model．Methods 21d，42d and 63d three different age groups of BALB/c mutant curly and normal BALB/c mice of 20 each，half male and half female，were selected to measure body weight，head length，body length，tail length and to compare the head body ratio，tail body ratio and organ coefficient．Results F4 generation BALB/c mutant curly has completely homozygous mice．Head body ratio，tail body ratio of mutant curly mice aged 21d and 42d were lower than those of normal mice (P< 0.05)，body weight，head body ratio，tail body ratio of mutant curly mice aged 63d were lower than those of normal mice (P< 0.05)．Heart，spleen，ovarian，uterine coefficient of 21d mutant mice were greater than those of normal mice (P< 0.05，P＜0.01)；heart and thymus coefficient of 42d mutation curly mice were lower than those of normal mice，brain and testis coefficient were higher than those of normal mice (P< 0.05，P< 0.01)；heart and uterus coefficient of 63d mutant curly mice lower than those of normal mice，brain coefficient was higher than those of normal mice (P<0.05，P< 0.01)．Conclusion There are differences in appearance and organ coefficient of BALB/c mutant curly and normal mice，these different mutations have very important significance for the study of BALB/c mutant curly mice growth，cardiovascular system，immune system and reproductive system．